Mechanisms of Glucocorticoid-Induced Insulin Resistance
نویسندگان
چکیده
منابع مشابه
New mechanisms of glucocorticoid-induced insulin resistance: make no bones about it.
Glucocorticoids are a powerful tool used to treat a range of human illnesses, including autoimmune diseases and cancer, and to prevent rejection following organ transplantation. While lifesaving for many, they come with a steep price, often leading to obesity, insulin resistance, diabetes, and osteoporosis. In this issue of the JCI, Brennan-Speranza and colleagues provide evidence that the oste...
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Sidibeh, C. O. 2018. Novel mechanisms of glucocorticoid-induced insulin resistance in human adipose tissue. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1408. 52 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0180-8. The global prevalence of obesity and type 2 diabetes (T2D) is increasing. From a public health perspective, it is therefore o...
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Glucocorticoids play a key role in metabolic adaptation during stress. The major metabolic function of glucocorticoids is to preserve plasma the glucose levels that serve as the major energy source for the brain [1]. Therefore, glucocorticoids antagonize the ability of insulin to suppress hepatic gluconeogenesis and promote glucose utilization in white adipose tissue (WAT) and skeletal muscle [...
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© 2012 Berrou et al., licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Molecular Mechanisms Conferring Resistance/Sensitivity to Glucocorticoid-Induced Apop...
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Glucocorticoids modify osteoblastic cell differentiation, number, and function. Glucocorticoids stimulate osteoclastogenesis and increase the expression of receptor activator of Nuclear factor-kappaB ligand and colony-stimulating factor-1, and decrease the expression of osteoprotegerin. However, the most significant effect of glucocorticoids in bone is an inhibition of bone formation. This inhi...
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ژورنال
عنوان ژورنال: Endocrinology and Metabolism Clinics of North America
سال: 2014
ISSN: 0889-8529
DOI: 10.1016/j.ecl.2013.10.005